Engineered Phage Endolysin Eliminates Gardnerella Biofilm without Damaging Beneficial Bacteria in Bacterial Vaginosis Ex Vivo
نویسندگان
چکیده
منابع مشابه
A fruitful alliance: the synergy between Atopobium vaginae and Gardnerella vaginalis in bacterial vaginosis-associated biofilm
OBJECTIVES Bacterial vaginosis (BV) is characterised by a change in the microbial composition of the vagina. The BV-associated organisms outnumber the health-associated Lactobacillus species and form a polymicrobial biofilm on the vaginal epithelium, possibly explaining the difficulties with antibiotic treatment. A better understanding of vaginal biofilm with emphasis on Atopobium vaginae and G...
متن کاملPrevalence and distribution of Gardnerella vaginalis subgroups in women with and without bacterial vaginosis
BACKGROUND Bacterial vaginosis (BV) is one of the leading causes of vaginal complaints among women of childbearing age. The role of Gardnerella vaginalis remains controversial due to its presence in healthy and BV-type vaginal microflora. The phenotypic and genotypic heterogeneity of G. vaginalis suggested the existence of strain variants linked with different health conditions. We sought to an...
متن کاملGardnerella vaginalis-associated bacterial vaginosis in Bulgarian women.
BACKGROUND Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women of reproductive age. The purpose of this study was to determine the frequency of BV in Bulgarian pregnant and nonpregnant women from several age ranges and to compare three different laboratory methods for Gardnerella vaginalis detection in patents suffering from BV. METHODS Between September 2011 and J...
متن کاملAntibiotic resistance of Gardnerella vaginalis in recurrent bacterial vaginosis.
Fifty strains of Gardnerella vaginalis isolated from 321 high vaginal swabs over a period of five months were tested for their antibiotic sensitivity. Sixty eight per cent of all isolates were resistant to metronidazole while 76% were sensitive to clindamycin. All the strains isolated from cases with recurrence of infection were resistant to metronidazole. Clindamycin therapy has a better clini...
متن کاملGardnerella vaginalis does not always cause bacterial vaginosis.
TO THE EDITOR—Schwebke et al [1] present a conceptual model arguing the case for Gardnerella vaginalis as the primary etiological agent of bacterial vaginosis (BV). The model posits that G. vaginalis is a sexually acquired pathogen that elicits BV via the establishment of a bacterial biofilm on the vaginal epithelium, aided by synergistic associations with vaginal anaerobes and competitive inte...
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ژورنال
عنوان ژورنال: Pathogens
سال: 2021
ISSN: 2076-0817
DOI: 10.3390/pathogens10010054